8U7X
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with inhibitor compound 24
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 539 | 62090.0 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) In PDB | Homo sapiens (human) | |
2 | A, B | (3S,4S)-8-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrido[2,3-b]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine | non-polymer | 458.0 | 2 | Chemie (WAB) | |||
3 | water | water | 18.0 | 664 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 525 (UniProt: Q06124)
PDB | External Database | Details |
---|---|---|
Met -13 | - | initiating methionine |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
Glu -6 | - | expression tag |
Asn -5 | - | expression tag |
Leu -4 | - | expression tag |
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 124179.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 916.0 | |
All* | Total formula weight | 125095.9 |