8U4I

Structure of the HER4/NRG1b Homodimer Extracellular Domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Receptor tyrosine-protein kinase erbB-4	polymer	610	68072.8	2	UniProt (Q15303) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB	Homo sapiens (human)	Proto-oncogene-like protein c-ErbB-4,Tyrosine kinase-type cell surface receptor HER4,p180erbB4
2	C, D	Isoform 6 of Pro-neuregulin-1, membrane-bound isoform	polymer	52	5890.8	2	UniProt (Q02297) Pfam (PF00008) In PDB	Homo sapiens (human)	Pro-NRG1
3	E, G, P, Q	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
4	F, H, I, K, L...	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	7	In PDB GlyTouCan (G22768VO)
5	J, O	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	N	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G22573RC)
7	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	147927.2
Branched	Number of molecules	14
	Total formula weight	10319.4
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	158689.1

*Water molecules are not included.