8U4I
Structure of the HER4/NRG1b Homodimer Extracellular Domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor tyrosine-protein kinase erbB-4 | polymer | 610 | 68072.8 | 2 | UniProt (Q15303) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Proto-oncogene-like protein c-ErbB-4,Tyrosine kinase-type cell surface receptor HER4,p180erbB4 |
| 2 | C, D (C, D) | Isoform 6 of Pro-neuregulin-1, membrane-bound isoform | polymer | 52 | 5890.8 | 2 | UniProt (Q02297) Pfam (PF00008) | Homo sapiens (human) | Pro-NRG1 |
| 3 | E, G, P, Q (E, G, P, Q) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 4 | F, H, I, K, L... (F, H, I, K, L...) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 7 | In PDB GlyTouCan (G22768VO) | |||
| 5 | J, O (J, O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | N (N) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 7 | S, T (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 147927.2 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 10319.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 158689.1 |
