8U3O
SARS-CoV-2 Main Protease A173V in complex with CDD-1819
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ORF1a polyprotein | polymer | 307 | 33910.6 | 2 | UniProt (A0A7U3H5H9) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 | |
| 2 | C, D (A, B) | (2P)-2-(isoquinolin-4-yl)-1-[(1s,3R)-3-(methylcarbamoyl)cyclobutyl]-N-[(1S)-1-(naphthalen-2-yl)ethyl]-1H-benzimidazole-7-carboxamide | non-polymer | 553.7 | 2 | Chemie (O69) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 535 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 306 (UniProt: A0A7U3H5H9)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 173 | Ala 3436 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67821.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1107.3 | |
| All* | Total formula weight | 68928.6 |
