8U1P
Local refinement of Plasmodium falciparum gametocyte surface protein Pfs48/45 Domains 1 and 2 in complex with neutralizing antibodies
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Gametocyte surface protein P45/48 | polymer | 401 | 46250.4 | 1 | UniProt (Q8I6T1) Pfam (PF07422) | Plasmodium falciparum 3D7 | |
| 2 | B (H) | RUPA154 Fab Heavy Chain | polymer | 226 | 24241.2 | 1 | Homo sapiens | ||
| 3 | C (L) | RUPA154 Fab Light Chain | polymer | 213 | 22898.4 | 1 | Homo sapiens | ||
| 4 | D (C) | RUPA58 Fab Light Chain | polymer | 213 | 23355.0 | 1 | Homo sapiens | ||
| 5 | E (B) | RUPA58 Fab Heavy Chain | polymer | 227 | 24416.4 | 1 | Homo sapiens | ||
| 6 | F, G (D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 7 | H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 28 - 428 (UniProt: Q8I6T1)
| PDB | External Database | Details |
|---|---|---|
| Tyr 308 | His 308 | conflict |
| Arg 361 | Ser 361 | conflict |
| Ser 373 | Asp 373 | conflict |
| Leu 397 | Gly 397 | conflict |
| Val 402 | Ile 402 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 141161.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 142231.4 |
