8U1F
FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Fibroblast growth factor receptor 2 | polymer | 316 | 36121.6 | 2 | UniProt (P21802) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
3 | A, B | N-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide | non-polymer | 493.6 | 2 | Chemie (UIM) | |||
4 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A, B: 458 - 768 (UniProt: P21802)
PDB | External Database | Details |
---|---|---|
Ser 453 | - | expression tag |
His 454 | - | expression tag |
Met 455 | - | expression tag |
Gly 456 | - | expression tag |
Ser 457 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 72243.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1175.3 | |
All* | Total formula weight | 73418.5 |