8U17

The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Protein cereblon	polymer	373	42971.6	2	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
2	B, E (B, E)	DNA damage-binding protein 1	polymer	836	93347.1	2	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
3	C, F (C, F)	Sal-like protein 4	polymer	86	9687.1	2	UniProt (Q9UJQ4) Pfam (PF00096)	Homo sapiens (human)
4	G, I, J, K, M... (A, C, D, F)	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
5	H, L (A, D)	S-Pomalidomide	non-polymer		273.2	2	Chemie (Y70)

Sequence modifications

B, E: 1 - 699 (UniProt: Q16531)
B, E: 706 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Gly 700	-	linker
Asn 701	-	linker
Gly 702	-	linker
Asn 703	-	linker
Ser 704	-	linker
Gly 705	-	linker

C, F: 370 - 454 (UniProt: Q9UJQ4)

PDB	External Database	Details
Ser 369	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	292011.5
Non-Polymers*	Number of molecules	8
	Total formula weight	938.9
All*	Total formula weight	292950.4

*Water molecules are not included.