8U0H

Crystal structure of PTPN2 with a PROTAC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	PTPN2	polymer	324	37966.0	2	UniProt (P17706) Pfam (PF00102) In PDB	Homo sapiens (human)	Mer tyrosine kinase domain, Tyrosine-protein phosphatase non-receptor type 2,T-cell protein-tyrosine phosphatase,TCPTP
2	A, B	(5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[2-(4-{3-[(3R)-2,6-dioxopiperidin-3-yl]-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl}piperidin-1-yl)acetamido]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid	non-polymer		977.5	2	Chemie (UB0)
3	A, B	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5		water	water		18.0	385	Chemie (HOH)

Sequence modifications

A, B: 1 - 314 (UniProt: P17706)

PDB	External Database	Details
Met -1	-	expression tag
Ala 0	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75932.0
Non-Polymers*	Number of molecules	5
	Total formula weight	2096.1
All*	Total formula weight	78028.1

*Water molecules are not included.