8TZY

CryoEM structure of non-neutralizing bivalent antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	CBH4B Heavy chain	polymer	253	27116.4	2		Homo sapiens (human)
2	B, E	CBH4B Light chain	polymer	233	25359.3	2		Homo sapiens (human)
3	C	envelope glycoprotein E2	polymer	291	32287.3	1	UniProt (A0A2P0NE18) Pfam (PF01560) In PDB	Hepatitis C virus (isolate 1)

Sequence modifications

C: 384 - 645 (UniProt: A0A2P0NE18)

PDB	External Database	Details
Met 363	-	expression tag
Glu 364	-	expression tag
Thr 365	-	expression tag
Asp 366	-	expression tag
Thr 367	-	expression tag
Leu 368	-	expression tag
Leu 369	-	expression tag
Leu 370	-	expression tag
Trp 371	-	expression tag
Val 372	-	expression tag
Leu 373	-	expression tag
Leu 374	-	expression tag
Leu 375	-	expression tag
Trp 376	-	expression tag
Val 377	-	expression tag
Pro 378	-	expression tag
Gly 379	-	expression tag
Ser 380	-	expression tag
Thr 381	-	expression tag
Gly 382	-	expression tag
Asp 383	-	expression tag
Ile 646	-	expression tag
Gly 647	-	expression tag
His 648	-	expression tag
His 649	-	expression tag
His 650	-	expression tag
His 651	-	expression tag
His 652	-	expression tag
His 653	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	137238.6
All*	Total formula weight	137238.6

*Water molecules are not included.