8TYO
Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Spike glycoprotein | polymer | 1240 | 137478.5 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
2 | D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
3 | C, A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 27 | Chemie (NAG) |
Sequence modifications
A, B, C: 19 - 1211 (UniProt: P0DTC2)
PDB | External Database | Details |
---|---|---|
Met -4 | - | initiating methionine |
Pro -3 | - | expression tag |
Leu -2 | - | expression tag |
Tyr -1 | - | expression tag |
Lys 0 | - | expression tag |
Leu 1 | - | expression tag |
Leu 2 | - | expression tag |
Asn 3 | - | expression tag |
Val 4 | - | expression tag |
Leu 5 | - | expression tag |
Trp 6 | - | expression tag |
Leu 7 | - | expression tag |
Val 8 | - | expression tag |
Ala 9 | - | expression tag |
Val 10 | - | expression tag |
Ser 11 | - | expression tag |
Asn 12 | - | expression tag |
Ala 13 | - | expression tag |
Gln 14 | - | expression tag |
Cys 15 | - | expression tag |
Val 16 | - | expression tag |
Asn 17 | - | expression tag |
Phe 18 | - | expression tag |
Ala 80 | Asp 80 | conflict |
Gly 215 | Asp 215 | conflict |
- | Leu 241 | deletion |
- | Leu 242 | deletion |
- | Ala 243 | deletion |
Asn 417 | Lys 417 | conflict |
Lys 484 | Glu 484 | conflict |
Tyr 501 | Asn 501 | conflict |
Gly 614 | Asp 614 | conflict |
Gly 682 | Arg 682 | conflict |
Ser 683 | Arg 683 | conflict |
Ser 685 | Arg 685 | conflict |
Val 701 | Ala 701 | conflict |
Pro 986 | Lys 986 | conflict |
Pro 987 | Val 987 | conflict |
Gly 1212 | - | expression tag |
Tyr 1213 | - | expression tag |
Ile 1214 | - | expression tag |
Pro 1215 | - | expression tag |
Glu 1216 | - | expression tag |
Ala 1217 | - | expression tag |
Pro 1218 | - | expression tag |
Arg 1219 | - | expression tag |
Asp 1220 | - | expression tag |
Gly 1221 | - | expression tag |
Gln 1222 | - | expression tag |
Ala 1223 | - | expression tag |
Tyr 1224 | - | expression tag |
Val 1225 | - | expression tag |
Arg 1226 | - | expression tag |
Lys 1227 | - | expression tag |
Asp 1228 | - | expression tag |
Gly 1229 | - | expression tag |
Glu 1230 | - | expression tag |
Trp 1231 | - | expression tag |
Val 1232 | - | expression tag |
Phe 1233 | - | expression tag |
Leu 1234 | - | expression tag |
Ser 1235 | - | expression tag |
Thr 1236 | - | expression tag |
Phe 1237 | - | expression tag |
Leu 1238 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 412435.4 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 27 |
Total formula weight | 5972.6 | |
All* | Total formula weight | 418832.4 |