8TYO
Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein | polymer | 1240 | 137478.5 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | AA, BA, CA, DA, E... (C, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 27 | Chemie (NAG) |
Sequence modifications
A, B, C: 19 - 1211 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Tyr -1 | - | expression tag |
| Lys 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Leu 2 | - | expression tag |
| Asn 3 | - | expression tag |
| Val 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Trp 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Val 8 | - | expression tag |
| Ala 9 | - | expression tag |
| Val 10 | - | expression tag |
| Ser 11 | - | expression tag |
| Asn 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Gln 14 | - | expression tag |
| Cys 15 | - | expression tag |
| Val 16 | - | expression tag |
| Asn 17 | - | expression tag |
| Phe 18 | - | expression tag |
| Ala 80 | Asp 80 | conflict |
| Gly 215 | Asp 215 | conflict |
| - | Leu 241 | deletion |
| - | Leu 242 | deletion |
| - | Ala 243 | deletion |
| Asn 417 | Lys 417 | conflict |
| Lys 484 | Glu 484 | conflict |
| Tyr 501 | Asn 501 | conflict |
| Gly 614 | Asp 614 | conflict |
| Gly 682 | Arg 682 | conflict |
| Ser 683 | Arg 683 | conflict |
| Ser 685 | Arg 685 | conflict |
| Val 701 | Ala 701 | conflict |
| Pro 986 | Lys 986 | conflict |
| Pro 987 | Val 987 | conflict |
| Gly 1212 | - | expression tag |
| Tyr 1213 | - | expression tag |
| Ile 1214 | - | expression tag |
| Pro 1215 | - | expression tag |
| Glu 1216 | - | expression tag |
| Ala 1217 | - | expression tag |
| Pro 1218 | - | expression tag |
| Arg 1219 | - | expression tag |
| Asp 1220 | - | expression tag |
| Gly 1221 | - | expression tag |
| Gln 1222 | - | expression tag |
| Ala 1223 | - | expression tag |
| Tyr 1224 | - | expression tag |
| Val 1225 | - | expression tag |
| Arg 1226 | - | expression tag |
| Lys 1227 | - | expression tag |
| Asp 1228 | - | expression tag |
| Gly 1229 | - | expression tag |
| Glu 1230 | - | expression tag |
| Trp 1231 | - | expression tag |
| Val 1232 | - | expression tag |
| Phe 1233 | - | expression tag |
| Leu 1234 | - | expression tag |
| Ser 1235 | - | expression tag |
| Thr 1236 | - | expression tag |
| Phe 1237 | - | expression tag |
| Leu 1238 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 412435.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 5972.6 | |
| All* | Total formula weight | 418832.4 |
