8TW6
TCR in nanodisc ND-II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H (Y, X) | T-cell surface glycoprotein CD3 zeta chain, GFP fusion protein,GFP | polymer | 412 | 46650.9 | 2 | UniProt (P20963) UniProt (A0A5P9VSM6) Pfam (PF11628) Pfam (PF02189) Pfam (PF01353) | Homo sapiens (human) | |
| 2 | B (A) | TCR alpha | polymer | 274 | 30388.2 | 1 | Homo sapiens (human) | ||
| 3 | C (B) | T cell receptor beta variable 6-5,T cell receptor beta chain MC.7.G5,MCHERRY | polymer | 556 | 62042.9 | 1 | UniProt (A0A0K0K1A5) UniProt (P0DTU4) UniProt (A0A4D6FVK6) Pfam (PF07686) Pfam (PF07654) Pfam (PF01353) | Homo sapiens (human) | TR beta chain TRBV25-1*01J2S3*01C2*01,MC.7.G5 TRB |
| 4 | D, E (E, F) | T-cell surface glycoprotein CD3 epsilon chain | polymer | 207 | 23174.2 | 2 | UniProt (P07766) Pfam (PF16681) Pfam (PF02189) | Homo sapiens (human) | T-cell surface antigen T3/Leu-4 epsilon chain |
| 5 | F (D) | T-cell surface glycoprotein CD3 delta chain | polymer | 171 | 18949.5 | 1 | UniProt (P04234) Pfam (PF16680) Pfam (PF02189) | Homo sapiens (human) | T-cell receptor T3 delta chain |
| 6 | G (G) | T-cell surface glycoprotein CD3 gamma chain | polymer | 190 | 21598.6 | 1 | UniProt (P09693) Pfam (PF16680) Pfam (PF02189) | Homo sapiens (human) | T-cell receptor T3 gamma chain |
| 7 | I (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 8 | J, K (Y, B) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 9 | L (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
Y, X: 1 - 164 (UniProt: P20963)
Y, X: 175 - 412 (UniProt: A0A5P9VSM6)
B: 1 - 114 (UniProt: A0A0K0K1A5)
B: 128 - 311 (UniProt: P0DTU4)
B: 322 - 556 (UniProt: A0A4D6FVK6)
G: 1 - 182 (UniProt: P09693)
| PDB | External Database | Details |
|---|---|---|
| Ala 165 | - | linker |
| Ser 166 | - | linker |
| Leu 167 | - | linker |
| Glu 168 | - | linker |
| Val 169 | - | linker |
| Leu 170 | - | linker |
| Phe 171 | - | linker |
| Gln 172 | - | linker |
| Gly 173 | - | linker |
| Pro 174 | - | linker |
B: 1 - 114 (UniProt: A0A0K0K1A5)
| PDB | External Database | Details |
|---|---|---|
| Val 115 | - | linker |
| Gly 116 | - | linker |
| Asn 117 | - | linker |
| Thr 118 | - | linker |
| Gly 119 | - | linker |
| Glu 120 | - | linker |
| Leu 121 | - | linker |
| Phe 122 | - | linker |
| Phe 123 | - | linker |
| Gly 124 | - | linker |
| Glu 125 | - | linker |
| Gly 126 | - | linker |
| Ser 127 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 312 | - | linker |
| Ser 313 | - | linker |
| Leu 314 | - | linker |
| Glu 315 | - | linker |
| Val 316 | - | linker |
| Leu 317 | - | linker |
| Phe 318 | - | linker |
| Gln 319 | - | linker |
| Gly 320 | - | linker |
| Pro 321 | - | linker |
G: 1 - 182 (UniProt: P09693)
| PDB | External Database | Details |
|---|---|---|
| His 183 | - | expression tag |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| His 190 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 272629.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 994.5 | |
| All* | Total formula weight | 274210.5 |
