8TU4
Bruton's tyrosine kinase in complex with covalent inhibitor compound 25
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase BTK | polymer | 283 | 32680.5 | 1 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
2 | A | N-methyl-N-[(1S,3r)-3-methyl-3-{[(6M,8S)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide | non-polymer | 368.4 | 1 | Chemie (V72) | |||
3 | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 382 - 659 (UniProt: Q06187)
PDB | External Database | Details |
---|---|---|
Gly 377 | - | expression tag |
Pro 378 | - | expression tag |
Leu 379 | - | expression tag |
Gly 380 | - | expression tag |
Ser 381 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32680.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 368.4 | |
All* | Total formula weight | 33048.9 |