8TS9
Human PI3K p85alpha/p110alpha H1047R bound to compound 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 1060 | 122860.0 | 1 | UniProt (P42336) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | |
2 | B | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 300 | 35960.1 | 1 | UniProt (P27986) Pfam (PF00017) Pfam (PF16454) In PDB | Homo sapiens (human) | |
3 | A | 5-[3-fluoro-5-(trifluoromethyl)benzamido]-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide | non-polymer | 446.4 | 1 | Chemie (UE9) |
Sequence modifications
A: 2 - 1050 (UniProt: P42336)
B: 318 - 615 (UniProt: P27986)
PDB | External Database | Details |
---|---|---|
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
Pro -7 | - | expression tag |
Gly -6 | - | expression tag |
Ile -5 | - | expression tag |
Ser -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Gly 0 | - | expression tag |
Gly 1 | - | expression tag |
Arg 1047 | His 1047 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 316 | - | expression tag |
Pro 317 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 158820.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 446.4 | |
All* | Total formula weight | 159266.6 |