8TRL
T cell recognition of citrullinated alpha-enolase peptide presented by HLA-DR4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (A, D) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 181 | 21084.8 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B, G (B, E) | HLA class II histocompatibility antigen, DRB1 beta chain | polymer | 190 | 22275.7 | 2 | UniProt (P01911) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | Human leukocyte antigen DRB1,HLA-DRB1 |
| 3 | C, H (C, F) | Alpha-enolase | polymer | 13 | 1421.5 | 2 | UniProt (by SIFTS) (P06733) | Homo sapiens | |
| 4 | D, I (I, G) | RA2.7 TCR alpha chain | polymer | 204 | 22717.1 | 2 | Homo sapiens (human) | ||
| 5 | E, J (J, H) | RA2.7 TCR beta chain | polymer | 245 | 28404.6 | 2 | Homo sapiens (human) | ||
| 6 | K (K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 7 | L (L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 1 | In PDB GlyTouCan (G94156YI) | |||
| 8 | M, S, V, Z (A, B, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 9 | HA, N, Q (H, A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 10 | O, P, U, W (A, J, D) | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
| 11 | AA, BA, CA, DA, EA... (E, G, A, B, D) | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) | |||
| 12 | IA, JA, KA, LA, MA... (A, B, C, I, J...) | water | water | 18.0 | 343 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 190 (UniProt: P01911)
| PDB | External Database | Details |
|---|---|---|
| Glu 9 | Trp 38 | variant |
| Val 11 | Pro 40 | variant |
| His 13 | Arg 42 | variant |
| His 33 | Asn 62 | variant |
| Tyr 37 | Ser 66 | variant |
| Tyr 47 | Phe 76 | variant |
| Leu 67 | Ile 96 | variant |
| Lys 71 | Ala 100 | variant |
| Gly 86 | Val 115 | variant |
| Tyr 96 | Gln 125 | variant |
| Glu 98 | Lys 127 | variant |
| Ala 104 | Ser 133 | variant |
| Asn 120 | Ser 149 | variant |
| Arg 133 | Leu 162 | variant |
| Thr 140 | Ala 169 | variant |
| Val 142 | Met 171 | variant |
| Leu 180 | Val 209 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 191807.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1538.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2259.1 | |
| All* | Total formula weight | 195605.0 |
