8TPY
Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R] 4-Guanin-9-yl-2-hydroxymethyl-1-N-(3-phosphonopropionyl)pyrrolidine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 218 | 24516.2 | 4 | UniProt (P00492) Pfam (PF00156) In PDB | Homo sapiens (human) | HGPRT,HGPRTase |
2 | A, B, C, D | {3-[(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-oxopropyl}phosphonic acid | non-polymer | 386.3 | 4 | Chemie (JG6) | |||
3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 217 (UniProt: P00492)
PDB | External Database | Details |
---|---|---|
Ala 22 | Cys 23 | engineered mutation |
Ala 105 | Cys 106 | engineered mutation |
Ala 205 | Cys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 98064.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1642.4 | |
All* | Total formula weight | 99707.3 |