8TPV
Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 218 | 24516.2 | 4 | UniProt (P00492) Pfam (PF00156) | Homo sapiens (human) | HGPRT,HGPRTase |
| 2 | E, H, K, N (A, B, C, D) | (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid | non-polymer | 494.3 | 4 | Chemie (JEI) | |||
| 3 | F, G, I, J, L... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 4 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 217 (UniProt: P00492)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ala 1 | - | expression tag |
| Thr 2 | - | expression tag |
| Ala 22 | Cys 23 | engineered mutation |
| Ala 105 | Cys 106 | engineered mutation |
| Ala 205 | Cys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 98064.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2171.8 | |
| All* | Total formula weight | 100236.6 |
