8TPV
Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 218 | 24516.2 | 4 | UniProt (P00492) Pfam (PF00156) In PDB | Homo sapiens (human) | HGPRT,HGPRTase |
2 | A, B, C, D | (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid | non-polymer | 494.3 | 4 | Chemie (JEI) | |||
3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
4 | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 217 (UniProt: P00492)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Ala 1 | - | expression tag |
Thr 2 | - | expression tag |
Ala 22 | Cys 23 | engineered mutation |
Ala 105 | Cys 106 | engineered mutation |
Ala 205 | Cys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 98064.9 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2171.8 | |
All* | Total formula weight | 100236.6 |