8TOX
Cryo-EM structure of BG505 Env mutant A517E in complex with antibody ACS202 Fab
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A, F | Envelope glycoprotein gp41 | polymer | 153 | 17134.4 | 3 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | G, C, I | Envelope glycoprotein gp120 | polymer | 475 | 53262.5 | 3 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
| 3 | H, D, J | antibody ACS202 Fab heavy chain | polymer | 236 | 25295.5 | 3 | Homo sapiens (human) | ||
| 4 | L, E, K | antibody ACS202 Fab light chain | polymer | 214 | 23470.2 | 3 | Homo sapiens (human) | ||
| 5 | 0, b, 1, d, e... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 33 | In PDB GlyTouCan (G42666HT) | |||
| 6 | c, 3, f, AA, m... | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 9 | In PDB GlyTouCan (G22768VO) | |||
| 7 | a, h, 8, Q, r... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
| 8 | 2, l, U | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G56014GC) | |||
| 9 | B, G, A, C, F... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) | |||
| 10 | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
B, A, F: 512 - 664 (UniProt: Q2N0S6)
G, C, I: 31 - 507 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Glu 517 | Ala 514 | engineered mutation |
| Asn 535 | Met 532 | engineered mutation |
| Gln 543 | Asn 540 | engineered mutation |
| Pro 559 | Ile 556 | engineered mutation |
| Gly 569 | Thr 566 | engineered mutation |
| Phe 573 | Ile 570 | engineered mutation |
| Glu 588 | Arg 585 | engineered mutation |
| Val 589 | Asp 586 | engineered mutation |
| Cys 605 | Thr 602 | engineered mutation |
| Gly 636 | Ser 633 | engineered mutation |
| Phe 651 | Asn 648 | engineered mutation |
| Ile 655 | Lys 652 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 201 | Ile 200 | engineered mutation |
| Ile 204 | Ala 203 | engineered mutation |
| Lys 240 | Pro 239 | engineered mutation |
| Asn 241 | Ser 240 | engineered mutation |
| Ile 285 | Leu 284 | engineered mutation |
| Met 302 | Asn 301 | engineered mutation |
| Leu 320 | Thr 317 | engineered mutation |
| Pro 329 | Ala 327 | engineered mutation |
| Phe 360 | Arg 358 | engineered mutation |
| Val 430 | Ile 427 | engineered mutation |
| Cys 433 | Ala 430 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 357487.6 | |
| Branched | Number of molecules | 51 |
| Total formula weight | 28940.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2654.5 | |
| All* | Total formula weight | 389082.9 |
