8TOV
HIV-CA Disulfide linked Hexamer bound to Quinazolin-4-one Scaffold inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (G, I, J, K, L...) | Matrix protein p17 | polymer | 231 | 25461.3 | 12 | UniProt (D2ECE2) Pfam (PF19317) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | M, N, O, P, Q... (G, I, J, K, L...) | 2-[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]-N-[(1R)-2-(3,5-difluorophenyl)-1-{3-[4-(morpholine-4-sulfonyl)phenyl]-4-oxo-3,4-dihydroquinazolin-2-yl}ethyl]acetamide | non-polymer | 821.9 | 12 | Chemie (J6U) | |||
| 3 | AA, BA, CA, DA, EA... (J, K, L, H, A...) | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
G, I, J, K, L, H, A, B, C, D, E, F: 1 - 231 (UniProt: D2ECE2)
| PDB | External Database | Details |
|---|---|---|
| Cys 14 | Ala 146 | engineered mutation |
| Cys 45 | Glu 177 | engineered mutation |
| Ala 184 | Trp 316 | engineered mutation |
| Ala 185 | Met 317 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 305535.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 9862.4 | |
| All* | Total formula weight | 315397.7 |
