8TOP
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | O, Q, S, A, C... | HIV-1 BG505 DS-SOSIP gp120 | polymer | 481 | 54086.3 | 6 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
2 | P, R, T, B, D... | HIV-1 BG505 DS-SOSIP glycoprotein gp41 | polymer | 153 | 17146.5 | 6 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | Env polyproten |
3 | H, J, M, U, W... | Heavy chain of antibody GPZ6-b.01 | polymer | 237 | 25294.4 | 6 | Macaca mulatta (Rhesus monkey) | ||
4 | K, L, N, V, X... | Light chain of antibody GPZ6-b.01 | polymer | 214 | 23162.6 | 6 | Macaca mulatta (Rhesus monkey) | ||
5 | a, c, e, g, h... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
6 | b, d, f, i, l... | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 6 | In PDB GlyTouCan (G81315DD) | |||
7 | Q, S, C, T, A... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 82 | Chemie (NAG) |
Sequence modifications
O, Q, S, A, C, E: 31 - 508 (UniProt: Q2N0S6)
P, R, T, B, D, F: 512 - 664 (UniProt: Q2N0S6)
PDB | External Database | Details |
---|---|---|
Cys 201 | Ile 200 | conflict |
Asn 332 | Thr 330 | conflict |
Cys 433 | Ala 430 | conflict |
Cys 501 | Ala 498 | conflict |
Arg 509 | - | expression tag |
Arg 510 | - | expression tag |
Arg 511 | - | expression tag |
Arg 512 | - | expression tag |
Arg 513 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | conflict |
Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 24 |
Total formula weight | 718138.9 | |
Branched | Number of molecules | 15 |
Total formula weight | 8311.7 | |
Non-Polymers* | Number of molecules | 82 |
Total formula weight | 18139.1 | |
All* | Total formula weight | 744589.7 |