8TNU
Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, J, H | TRNM-b*01 heavy chain | polymer | 226 | 24706.6 | 3 | Macaca mulatta (Rhesus monkey) | ||
2 | C, K, L | TRNM-b*01 light chain | polymer | 213 | 23050.6 | 3 | Macaca mulatta (Rhesus monkey) | ||
3 | Z, X, Y | Transmembrane protein gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S5) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
4 | G, E, F | BG505 DS-SOSIP Surface protein gp120 | polymer | 481 | 54086.3 | 3 | UniProt (Q2N0S5) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
5 | b, c, e, f, h... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 17 | In PDB GlyTouCan (G42666HT) | |||
6 | R, W | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
7 | a, d, g, i | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
8 | E, F, Z, G, X... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 37 | Chemie (NAG) |
Sequence modifications
Z, X, Y: 512 - 664 (UniProt: Q2N0S5)
G, E, F: 31 - 511 (UniProt: Q2N0S5)
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | conflict |
Cys 605 | Thr 602 | conflict |
PDB | External Database | Details |
---|---|---|
Cys 201 | Ile 200 | engineered mutation |
Asn 332 | Thr 330 | engineered mutation |
Cys 433 | Ala 430 | engineered mutation |
Cys 501 | Ala 498 | engineered mutation |
Arg 509 | Glu 506 | engineered mutation |
Arg 510 | Lys 507 | engineered mutation |
Arg 512 | - | insertion |
Arg 513 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 356970.1 | |
Branched | Number of molecules | 23 |
Total formula weight | 11382.6 | |
Non-Polymers* | Number of molecules | 37 |
Total formula weight | 8184.7 | |
All* | Total formula weight | 376537.4 |