8TNJ
Cryo-EM structure of HLA-B*73:01 bound to a 9mer peptide and two Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 9mer peptide,Beta-2-microglobulin,MHC class I antigen chimera | polymer | 439 | 49165.8 | 1 | UniProt (P61771) UniProt (A0A583ZBV1) Pfam (PF07654) UniProt (by SIFTS) (P61769) UniProt (by SIFTS) (A0A858LJX3) | Homo sapiens | |
| 2 | B (C) | B.8 Fab light chain | polymer | 216 | 23523.1 | 1 | Homo sapiens | ||
| 3 | C (D) | B.8 Fab heavy chain | polymer | 232 | 24684.6 | 1 | Homo sapiens | ||
| 4 | D (E) | B.1 Fab heavy chain | polymer | 238 | 25284.0 | 1 | Homo sapiens | ||
| 5 | E (F) | B.1 Fab light chain | polymer | 215 | 23478.1 | 1 | Homo sapiens |
Sequence modifications
A: 25 - 123 (UniProt: P61771)
A: 145 - 423 (UniProt: A0A583ZBV1)
| PDB | External Database | Details |
|---|---|---|
| Asn 1 | - | insertion |
| Arg 2 | - | insertion |
| Phe 3 | - | insertion |
| Leu 4 | - | insertion |
| Gly 5 | - | insertion |
| Asp 6 | - | insertion |
| Tyr 7 | - | insertion |
| Val 8 | - | insertion |
| Val 9 | - | insertion |
| Gly 10 | - | linker |
| Gly 11 | - | linker |
| Gly 12 | - | linker |
| Gly 13 | - | linker |
| Ser 14 | - | linker |
| Gly 15 | - | linker |
| Gly 16 | - | linker |
| Gly 17 | - | linker |
| Gly 18 | - | linker |
| Ser 19 | - | linker |
| Gly 20 | - | linker |
| Gly 21 | - | linker |
| Gly 22 | - | linker |
| Gly 23 | - | linker |
| Ser 24 | - | linker |
| Gly 125 | - | linker |
| Gly 126 | - | linker |
| Gly 127 | - | linker |
| Gly 128 | - | linker |
| Ser 129 | - | linker |
| Gly 130 | - | linker |
| Gly 131 | - | linker |
| Gly 132 | - | linker |
| Gly 133 | - | linker |
| Ser 134 | - | linker |
| Gly 135 | - | linker |
| Gly 136 | - | linker |
| Gly 137 | - | linker |
| Gly 138 | - | linker |
| Ser 139 | - | linker |
| Gly 140 | - | linker |
| Gly 141 | - | linker |
| Gly 142 | - | linker |
| Gly 143 | - | linker |
| Ser 144 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 414 | Cys 294 | conflict |
| Gly 421 | - | insertion |
| Gly 422 | Ser 301 | conflict |
| Gly 424 | - | expression tag |
| Leu 425 | - | expression tag |
| Glu 426 | - | expression tag |
| Val 427 | - | expression tag |
| Leu 428 | - | expression tag |
| Phe 429 | - | expression tag |
| Gln 430 | - | expression tag |
| Gly 431 | - | expression tag |
| Pro 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
| His 437 | - | expression tag |
| His 438 | - | expression tag |
| His 439 | - | expression tag |
| His 440 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 146135.6 | |
| All* | Total formula weight | 146135.6 |
