8TLC

Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine hydroxymethyltransferase, mitochondrial	polymer	493	54834.0	2	UniProt (P34897) Pfam (PF00464)	Homo sapiens (human)
2	C (A)	N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid	non-polymer		731.7	1	Chemie (I6I)
3	D (A)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, B: 29 - 504 (UniProt: P34897)

PDB	External Database	Details
Met 12	-	initiating methionine
Gly 13	-	expression tag
Ser 14	-	expression tag
Ser 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
Ser 22	-	expression tag
Ser 23	-	expression tag
Gly 24	-	expression tag
Leu 25	-	expression tag
Val 26	-	expression tag
Pro 27	-	expression tag
Arg 28	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	109668.1
Non-Polymers*	Number of molecules	1
	Total formula weight	731.7
All*	Total formula weight	110399.8

*Water molecules are not included.