8TJR
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | J, H | Antibody HERH-a.01 Heavy Chain | polymer | 114 | 12659.1 | 2 | Macaca | ||
2 | K, L | Antibody HERH-a.01 Light Chain | polymer | 112 | 12193.7 | 2 | Macaca | ||
3 | A, B, C | Envelope glycoprotein gp160 | polymer | 475 | 53143.2 | 3 | UniProt (Q2N0S6) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
4 | D, E, F | Envelope glycoprotein gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
5 | P, U, X | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G56014GC) | |||
6 | Q, R, V, W, Y... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
7 | A, C, D, B, F... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 48 | Chemie (NAG) |
Sequence modifications
A, B, C: 31 - 516 (UniProt: Q2N0S6)
D, E, F: 512 - 664 (UniProt: Q2N0S6)
PDB | External Database | Details |
---|---|---|
Cys 210 | Ile 200 | conflict |
Asn 341 | Thr 330 | conflict |
Cys 442 | Ala 430 | conflict |
Cys 510 | Ala 498 | conflict |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | engineered mutation |
Cys 605 | Thr 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 260574.5 | |
Branched | Number of molecules | 9 |
Total formula weight | 5765.3 | |
Non-Polymers* | Number of molecules | 48 |
Total formula weight | 10618.0 | |
All* | Total formula weight | 276957.8 |