8TIN

Human ACKR3 phosphorylated by GRK2 in complex with Arrestin3 reconstructed without receptor/micelle

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Fab7 heavy chain	polymer	240	25720.8	1		synthetic construct
2	B (A)	Beta-arrestin-2	polymer	392	44106.3	1	UniProt (P32120) Pfam (PF00339) Pfam (PF02752)	Bos taurus (cattle)	Arrestin beta-2,Arrestin-3
3	C (L)	Fab7 light chain	polymer	215	23471.0	1		synthetic construct
4	D (R)	Atypical chemokine receptor 3	polymer	393	45356.4	1	UniProt (P25106) Pfam (PF00001)	Homo sapiens (human)	C-X-C chemokine receptor type 7,CXC-R7,CXCR-7,Chemokine orphan receptor 1,G-protein coupled receptor 159,G-protein coupled receptor RDC1 homolog,RDC-1

Sequence modifications

A: 1 - 392 (UniProt: P32120)

PDB	External Database	Details
Val 362	Ala 362	conflict

R: 2 - 362 (UniProt: P25106)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Gly 363	-	expression tag
Arg 364	-	expression tag
Pro 365	-	expression tag
Leu 366	-	expression tag
Glu 367	-	expression tag
Val 368	-	expression tag
Leu 369	-	expression tag
Phe 370	-	expression tag
Gln 371	-	expression tag
Gly 372	-	expression tag
Pro 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
Asp 384	-	expression tag
Tyr 385	-	expression tag
Lys 386	-	expression tag
Asp 387	-	expression tag
Asp 388	-	expression tag
Asp 389	-	expression tag
Asp 390	-	expression tag
Lys 391	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	138654.5
All*	Total formula weight	138654.5

*Water molecules are not included.