8THZ
CryoEM structure of neutralizing antibodies CBH-7 and HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | CBH-7 Heavy chain | polymer | 254 | 27417.7 | 1 | Homo sapiens (human) | ||
| 2 | B (L) | CBH-7 Light chain | polymer | 235 | 25477.7 | 1 | Homo sapiens (human) | ||
| 3 | C (A) | envelope glycoprotein E2 | polymer | 291 | 32287.3 | 1 | UniProt (X4ZFZ7) Pfam (PF01560) | Hepacivirus C | |
| 4 | D (E) | HC84.26 Heavy chain | polymer | 268 | 28356.8 | 1 | Homo sapiens (human) | ||
| 5 | E (F) | HC84.26 Light chain | polymer | 234 | 25352.2 | 1 | Homo sapiens (human) | ||
| 6 | F, H (N, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G79924RM) | |||
| 8 | I (D) | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G31886NL) | |||
| 9 | J (G) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G89225LT) |
Sequence modifications
A: 384 - 645 (UniProt: X4ZFZ7)
| PDB | External Database | Details |
|---|---|---|
| Met 363 | - | initiating methionine |
| Glu 364 | - | expression tag |
| Thr 365 | - | expression tag |
| Asp 366 | - | expression tag |
| Thr 367 | - | expression tag |
| Leu 368 | - | expression tag |
| Leu 369 | - | expression tag |
| Leu 370 | - | expression tag |
| Trp 371 | - | expression tag |
| Val 372 | - | expression tag |
| Leu 373 | - | expression tag |
| Leu 374 | - | expression tag |
| Leu 375 | - | expression tag |
| Trp 376 | - | expression tag |
| Val 377 | - | expression tag |
| Pro 378 | - | expression tag |
| Gly 379 | - | expression tag |
| Ser 380 | - | expression tag |
| Thr 381 | - | expression tag |
| Gly 382 | - | expression tag |
| Asp 383 | - | expression tag |
| Ile 646 | - | expression tag |
| Gly 647 | - | expression tag |
| His 648 | - | expression tag |
| His 649 | - | expression tag |
| His 650 | - | expression tag |
| His 651 | - | expression tag |
| His 652 | - | expression tag |
| His 653 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 138891.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2932.7 | |
| All* | Total formula weight | 141824.3 |
