8THG

Cryo-EM structure of Nav1.7 with RLZ

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sodium channel protein type 9 subunit alpha	polymer	1988	226620.0	1	UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) Pfam (PF08016)	Homo sapiens (human)	Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7
2	B (B)	Sodium channel subunit beta-1	polymer	218	24732.1	1	UniProt (Q07699) Pfam (PF07686)	Homo sapiens (human)
3	C (C)	Sodium channel subunit beta-2	polymer	215	24355.9	1	UniProt (O60939) Pfam (PF07686)	Homo sapiens (human)
4	D, E, F (D, E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
5	G, H, U, V, W (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
6	I (A)	6-(trifluoromethoxy)-1,3-benzothiazol-2-amine	non-polymer		234.2	1	Chemie (657)
7	J, K, T (A)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	3	Chemie (Y01)
8	L, M, P, Q, R... (A)	1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		510.7	6	Chemie (LPE)
9	N (A)	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	1	Chemie (PCW)
10	O (A)	O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine	non-polymer		792.1	1	Chemie (P5S)
11	X (A)	water	water		18.0	4	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	275708.0
Branched	Number of molecules	3
	Total formula weight	1273.2
Non-Polymers*	Number of molecules	17
	Total formula weight	7443.9
All*	Total formula weight	284425.1

*Water molecules are not included.