8TGT

Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	M protein	polymer	104	12760.4	2	UniProt (Q6V9M3) UniProt (by SIFTS) (A0A059T9V1)	Streptococcus pyogenes
2	C (C)	C4b-binding protein alpha chain	polymer	128	14163.9	1	UniProt (P04003) Pfam (PF00084)	Homo sapiens (human)	C4bp,Proline-rich protein,PRP
3	D, E, F, G, I (A, B, C)	CALCIUM ION	non-polymer		40.1	5	Chemie (CA)
4	H (C)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	J, K, L (A, B, C)	water	water		18.0	20	Chemie (HOH)

Sequence modifications

A, B: 42 - 141 (UniProt: Q6V9M3)

PDB	External Database	Details
Gly 38	-	expression tag
Pro 39	-	expression tag
Gly 40	-	expression tag
Ser 41	-	expression tag

C: 1 - 124 (UniProt: P04003)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	39684.7
Non-Polymers*	Number of molecules	6
	Total formula weight	262.5
All*	Total formula weight	39947.1

*Water molecules are not included.