8TG9
Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Atrial natriuretic peptide receptor 1 | polymer | 469 | 52263.7 | 2 | UniProt (P16066) Pfam (PF01094) | Homo sapiens (human) | Atrial natriuretic peptide receptor type A,ANP-A,ANPR-A,NPR-A,Guanylate cyclase A,GC-A |
| 2 | C (C) | Atrial natriuretic peptide | polymer | 28 | 3087.5 | 1 | UniProt (P01160) Pfam (PF00212) | Homo sapiens | ANP,Alpha-atrial natriuretic peptide,Alpha-hANP,Atrial natriuretic factor,ANF,CDD-ANF,CDD-ANP (99-126),Cardionatrin,Pro atrial natriuretic factor 99-126,proANF 99-126 |
| 3 | D, F (H, E) | REGN5381 Fab heavy chain | polymer | 229 | 24818.8 | 2 | Mus musculus (mouse) | ||
| 4 | E, G (L, F) | REGN5381 Fab light chain | polymer | 213 | 23323.9 | 2 | Mus musculus (mouse) | ||
| 5 | H, J (D, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | I (G) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 7 | K (J) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 8 | L, M (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A, B: 1 - 441 (UniProt: P16066)
| PDB | External Database | Details |
|---|---|---|
| Glu 442 | - | expression tag |
| Gln 443 | - | expression tag |
| Lys 444 | - | expression tag |
| Leu 445 | - | expression tag |
| Ile 446 | - | expression tag |
| Ser 447 | - | expression tag |
| Glu 448 | - | expression tag |
| Glu 449 | - | expression tag |
| Asp 450 | - | expression tag |
| Leu 451 | - | expression tag |
| Gly 452 | - | expression tag |
| Gly 453 | - | expression tag |
| Glu 454 | - | expression tag |
| Gln 455 | - | expression tag |
| Lys 456 | - | expression tag |
| Leu 457 | - | expression tag |
| Ile 458 | - | expression tag |
| Ser 459 | - | expression tag |
| Glu 460 | - | expression tag |
| Glu 461 | - | expression tag |
| Asp 462 | - | expression tag |
| Leu 463 | - | expression tag |
| His 464 | - | expression tag |
| His 465 | - | expression tag |
| His 466 | - | expression tag |
| His 467 | - | expression tag |
| His 468 | - | expression tag |
| His 469 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 203900.3 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2508.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 206851.0 |
