8TD8
Structure of PYCR1 complexed with NADH and 2S-Hydroxy-3,3-dimethylbutyric acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Pyrroline-5-carboxylate reductase 1, mitochondrial | polymer | 316 | 33532.6 | 5 | UniProt (P32322) Pfam (PF03807) Pfam (PF14748) | Homo sapiens (human) | P5C reductase 1,P5CR 1 |
| 2 | F, H, K, M, O (A, B, C, D, E) | (2S)-2-hydroxy-3,3-dimethylbutanoic acid | non-polymer | 132.2 | 5 | Chemie (G8I) PubChem (107211) PubChem (11097105) PubChem (11344038) | |||
| 3 | G, I, L, N, P (A, B, C, D, E) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 5 | Chemie (NAI) PubChem (16219774) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (140875346) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (94865921) PubChem (94865923) PubChem (928) PubChem (124432988) PubChem (124934831) PubChem (124934833) PubChem (11250888) PubChem (129607000) PubChem (129628338) PubChem (12309341) PubChem (146167236) PubChem (162951602) PubChem (174084875) | |||
| 4 | J, Q (B, E) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | R, S, T, U, V (A, B, C, D, E) | water | water | 18.0 | 764 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 294 (UniProt: P32322)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | initiating methionine |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Val -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Thr -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 167662.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4180.1 | |
| All* | Total formula weight | 171843.0 |
