8TBI
Tricomplex of RMC-7977, NRAS WT, and CypA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | GTPase NRas | polymer | 173 | 19658.3 | 2 | UniProt (P01111) Pfam (PF00071) In PDB | Homo sapiens (human) | Transforming protein N-Ras |
2 | C, D | Peptidyl-prolyl cis-trans isomerase A | polymer | 166 | 18123.6 | 2 | UniProt (P62937) Pfam (PF00160) In PDB | Homo sapiens (human) | PPIase A,Cyclophilin A,Cyclosporin A-binding protein,Rotamase A |
3 | A, B | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | C, D | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide | non-polymer | 865.1 | 2 | Chemie (ZNI) | |||
6 | water | water | 18.0 | 736 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 172 (UniProt: P01111)
C, D: 1 - 165 (UniProt: P62937)
PDB | External Database | Details |
---|---|---|
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 75563.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2823.2 | |
All* | Total formula weight | 78387.0 |