8TBG
Tricomplex of RMC-7977, HRAS WT, and CypA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GTPase HRas | polymer | 167 | 18932.2 | 2 | UniProt (P01112) Pfam (PF00071) | Homo sapiens (human) | H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras |
| 2 | C, D (C, D) | Peptidyl-prolyl cis-trans isomerase A | polymer | 166 | 18123.6 | 2 | UniProt (P62937) Pfam (PF00160) | Homo sapiens (human) | PPIase A,Cyclophilin A,Cyclosporin A-binding protein,Rotamase A |
| 3 | E, G (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
| 4 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | I (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | J, K (C, D) | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide | non-polymer | 865.1 | 2 | Chemie (ZNI) | |||
| 7 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 846 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 166 (UniProt: P01112)
C, D: 1 - 165 (UniProt: P62937)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74111.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2915.3 | |
| All* | Total formula weight | 77026.9 |
