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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8TB9

PRC2-J119-450 monomer bound to H1-nucleosome

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Histone H1.0polymer19721209.51UniProt (P07305)
Pfam (PF00538)		Homo sapiens (human)Histone H1',Histone H1(0)
2B
(B)		Protein Jumonjipolymer33436251.71UniProt (Q92833)Homo sapiens (human)Jumonji/ARID domain-containing protein 2
3C
(D)		Polycomb protein SUZ12polymer61972266.41UniProt (Q15022)
Pfam (PF23320)
Pfam (PF09733)		Homo sapiens (human)Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
4D
(E)		Histone-lysine N-methyltransferase EZH2polymer75386175.01UniProt (Q15910)
Pfam (PF11616)
Pfam (PF18118)
Pfam (PF21358)
Pfam (PF18264)
Pfam (PF00856)		Homo sapiens (human)ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
5E
(G)		Polycomb protein EEDpolymer44150267.71UniProt (O75530)
Pfam (PF00400)		Homo sapiens (human)hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
6F
(H)		DNA (226-MER)polymer21566539.31synthetic construct
7G, O
(I, W)		Histone H3.2polymer13615435.12UniProt (P84233)
Pfam (PF00125)		Xenopus laevis (African clawed frog)
8H, P
(J, X)		Histone H4polymer10611625.62UniProt (P62799)
Pfam (PF15511)		Xenopus laevis (African clawed frog)
9I
(O)		Histone-binding protein RBBP4polymer42547709.51UniProt (Q09028)
Pfam (PF12265)
Pfam (PF00400)		Homo sapiens (human)Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48
10J, M
(R, U)		Histone H2A type 1polymer13314355.72UniProt (P06897)
Pfam (PF00125)
Pfam (PF16211)		Xenopus laevis (African clawed frog)
11K, N
(S, V)		Histone H2B 1.1polymer12313655.92UniProt (P02281)
Pfam (PF00125)		Xenopus laevis (African clawed frog)H2B1.1
12L
(T)		DNA (226-MER)polymer21565905.91synthetic construct
13Q
(Y)		Zinc finger protein AEBP2polymer30334183.21UniProt (Q6ZN18)
Pfam (PF26014)		Homo sapiens (human)Adipocyte enhancer-binding protein 2,AE-binding protein 2
14R
(E)		S-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
PubChem (16760024)
PubChem (193)
PubChem (25210495)
PubChem (13792)
PubChem (177678424)
PubChem (44361184)
PubChem (21125603)
PubChem (46936206)
PubChem (50989525)
PubChem (25203782)
PubChem (51380914)
PubChem (52224398)
PubChem (189149)
PubChem (57544532)
PubChem (439155)
PubChem (59046843)
PubChem (59170628)
PubChem (59576228)
PubChem (66805708)
PubChem (70689219)
PubChem (70702054)
PubChem (70832431)
PubChem (52224400)
PubChem (5284331)
PubChem (6419189)
PubChem (118374891)
PubChem (118560068)
PubChem (71170554)
PubChem (13231890)
PubChem (164157219)
PubChem (126969526)
PubChem (129105892)
PubChem (143518505)
PubChem (154578335)
PubChem (163054214)
PubChem (163335525)
Sequence modifications
A: 0 - 193 (UniProt: P07305)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
B: 119 - 450 (UniProt: Q92833)
PDBExternal DatabaseDetails
Met 117-initiating methionine
Val 118-expression tag
D: 68 - 685 (UniProt: Q15022)
PDBExternal DatabaseDetails
Met 67-initiating methionine
E: 2 - 751 (UniProt: Q15910)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
Ala 1-expression tag
Ala 14Cys 14conflict
Cys 15Trp 15conflict
I, W: 0 - 135 (UniProt: P84233)
PDBExternal DatabaseDetails
Ala 102Gly 103conflict
J, X: 0 - 102 (UniProt: P62799)
PDBExternal DatabaseDetails
Ser 103-expression tag
Ser 104-expression tag
Gly 105-expression tag
R, U: 0 - 129 (UniProt: P06897)
PDBExternal DatabaseDetails
Ser -3-expression tag
Asn -2-expression tag
Ala -1-expression tag
Arg 99Gly 100conflict
Cys 119Lys 120conflict
Ser 123Ala 124conflict
S, V: 1 - 122 (UniProt: P02281)
PDBExternal DatabaseDetails
Met 0-initiating methionine
Thr 29Ser 33conflict
Y: 10 - 309 (UniProt: Q6ZN18)
PDBExternal DatabaseDetails
Ser 7-expression tag
Asn 8-expression tag
Ala 9-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains17
Total formula weight590652.8
Non-Polymers*Number of molecules1
Total formula weight384.4
All*Total formula weight591037.2
*Water molecules are not included.

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PDB entries from 2026-05-06

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