8TB6

TYK2 JH2 bound to Compound14

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Non-receptor tyrosine-protein kinase TYK2	polymer	326	36493.3	2	UniProt (P29597) Pfam (PF07714)	Homo sapiens (human)
2	C, D (A, B)	N-[(3M)-3-{6-[(3R)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1H-pyrrolo[2,3-c]pyridin-5-yl]urea	non-polymer		367.4	2	Chemie (ZOI)
3	E, F (A, B)	water	water		18.0	242	Chemie (HOH)

Sequence modifications

A, B: 566 - 870 (UniProt: P29597)

PDB	External Database	Details
Ala 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag
Gly 556	-	expression tag
Ala 557	-	expression tag
Leu 558	-	expression tag
Glu 559	-	expression tag
Val 560	-	expression tag
Leu 561	-	expression tag
Phe 562	-	expression tag
Gln 563	-	expression tag
Gly 564	-	expression tag
Pro 565	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72986.6
Non-Polymers*	Number of molecules	2
	Total formula weight	734.8
All*	Total formula weight	73721.4

*Water molecules are not included.