8T9A

CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA damage-binding protein 1	polymer	1140	127097.5	1	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	B	DDB1- and CUL4-associated factor 12	polymer	471	52760.5	1	UniProt (Q5T6F0) Pfam (PF00400) In PDB	Homo sapiens (human)	Centrosome-related protein TCC52,Testis cancer centrosome-related protein,WD repeat-containing protein 40A
3	C	Melanoma-associated antigen 3	polymer	212	24032.8	1	UniProt (P43357) Pfam (PF01454) In PDB	Homo sapiens (human)	Antigen MZ2-D,Cancer/testis antigen 1.3,CT1.3,MAGE-3 antigen

Sequence modifications

B: 1 - 453 (UniProt: Q5T6F0)

PDB	External Database	Details
Met -17	-	initiating methionine
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Gln 131	Arg 131	variant

C: 104 - 314 (UniProt: P43357)

PDB	External Database	Details
Met 103	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	203890.7
All*	Total formula weight	203890.7

*Water molecules are not included.