8T6J

CDPPB-bound inactive mGlu5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Metabotropic glutamate receptor 5	polymer	881	98868.3	2	UniProt (P41594) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003)	Homo sapiens (human)	mGluR5
2	C, D (B, A)	3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide	non-polymer		364.4	2	Chemie (YKU)

Sequence modifications

B, A: 20 - 876 (UniProt: P41594)

PDB	External Database	Details
Met -4	-	initiating methionine
Lys -3	-	expression tag
Thr -2	-	expression tag
Ile -1	-	expression tag
Ile 0	-	expression tag
Ala 1	-	expression tag
Leu 2	-	expression tag
Ser 3	-	expression tag
Tyr 4	-	expression tag
Ile 5	-	expression tag
Phe 6	-	expression tag
Cys 7	-	expression tag
Leu 8	-	expression tag
Val 9	-	expression tag
Phe 10	-	expression tag
Ala 11	-	expression tag
Asp 12	-	expression tag
Tyr 13	-	expression tag
Lys 14	-	expression tag
Asp 15	-	expression tag
Asp 16	-	expression tag
Asp 17	-	expression tag
Asp 18	-	expression tag
Ala 19	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	197736.6
Non-Polymers*	Number of molecules	2
	Total formula weight	728.8
All*	Total formula weight	198465.4

*Water molecules are not included.