8T6G
Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 526 | 60335.0 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
3 | A, B | (1S)-1-{6-[(1S)-1-amino-1,3-dihydrospiro[indene-2,4'-piperidin]-1'-yl]-3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-5-yl}ethan-1-ol | non-polymer | 496.6 | 2 | Chemie (YT2) | |||
4 | water | water | 18.0 | 741 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 525 (UniProt: Q06124)
PDB | External Database | Details |
---|---|---|
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 120670.1 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 2242.0 | |
All* | Total formula weight | 122912.1 |