8T6D
Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 526 | 60335.0 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
| 2 | C, D, E, F, G... (A, B) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 3 | H, M (A, B) | (3R)-1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-3H-spiro[[1]benzofuran-2,4'-piperidin]-3-amine | non-polymer | 454.5 | 2 | Chemie (YR2) | |||
| 4 | N, O (A, B) | water | water | 18.0 | 259 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 525 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 120670.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1773.6 | |
| All* | Total formula weight | 122443.7 |
