8T55

Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	WD repeat-containing protein 91	polymer	359	39515.8	3	UniProt (A4D1P6) Pfam (PF00400) In PDB	Homo sapiens (human)
2	A, B, C	N-[3-(4-chlorophenyl)oxetan-3-yl]-1-propanoyl-1,2,3,4-tetrahydroquinoline-5-carboxamide	non-polymer		398.9	3	Chemie (ZI3)
3	B	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4		water	water		18.0	234	Chemie (HOH)

Sequence modifications

A, B, C: 392 - 732 (UniProt: A4D1P6)

PDB	External Database	Details
Met 374	-	initiating methionine
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag
His 379	-	expression tag
His 380	-	expression tag
Ser 381	-	expression tag
Ser 382	-	expression tag
Gly 383	-	expression tag
Arg 384	-	expression tag
Glu 385	-	expression tag
Asn 386	-	expression tag
Leu 387	-	expression tag
Tyr 388	-	expression tag
Phe 389	-	expression tag
Gln 390	-	expression tag
Gly 391	-	expression tag
-	Val 523	deletion
-	Asp 524	deletion
-	Phe 525	deletion
-	Ser 526	deletion
-	Ala 527	deletion
-	Pro 528	deletion
-	Asp 529	deletion
-	Ile 530	deletion
-	Gly 531	deletion
-	Ser 532	deletion
-	Lys 533	deletion
-	Gly 534	deletion
-	Met 535	deletion
-	Asn 536	deletion
-	Gln 537	deletion

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	118547.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1258.7
All*	Total formula weight	119806.1

*Water molecules are not included.