8T4P
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and di-glutamate AGF347 inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine hydroxymethyltransferase, mitochondrial | polymer | 493 | 54635.9 | 2 | UniProt (P34897) Pfam (PF00464) In PDB | Homo sapiens (human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
2 | A, B | N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE] | non-polymer | 306.2 | 2 | Chemie (PLG) | |||
3 | A | N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-gamma-glutamyl-L-glutamic acid | non-polymer | 602.6 | 1 | Chemie (Y5Z) | |||
4 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 504 (UniProt: P34897)
PDB | External Database | Details |
---|---|---|
Met 12 | - | initiating methionine |
Gly 13 | - | expression tag |
Ser 14 | - | expression tag |
Ser 15 | - | expression tag |
His 16 | - | expression tag |
His 17 | - | expression tag |
His 18 | - | expression tag |
His 19 | - | expression tag |
His 20 | - | expression tag |
His 21 | - | expression tag |
Ser 22 | - | expression tag |
Ser 23 | - | expression tag |
Gly 24 | - | expression tag |
Leu 25 | - | expression tag |
Val 26 | - | expression tag |
Pro 27 | - | expression tag |
Arg 28 | - | expression tag |
Thr 418 | Ala 418 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 109271.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1215.0 | |
All* | Total formula weight | 110486.9 |