8T2V

Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Integrin alpha-IIb	polymer	1008	110106.4	1	UniProt (P08514) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) Pfam (PF00357)	Homo sapiens (human)	GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb
2	B (B)	Integrin beta-3	polymer	762	84478.5	1	UniProt (P05106) Pfam (PF23105) Pfam (PF07974) Pfam (PF07965) Pfam (PF08725) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372)	Homo sapiens (human)	Platelet membrane glycoprotein IIIa,GPIIIa
3	C, D (C, E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	E (F)	beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G89225LT)
5	F (G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	G (H)	beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G40894EI)
7	H, I, J, K, P... (A, B)	CALCIUM ION	non-polymer		40.1	7	Chemie (CA)
8	L, M, N, O, Q... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
9	R, S (B)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)
10	T (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
11	X (B)	water	water		18.0	6	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	194584.9
Branched	Number of molecules	5
	Total formula weight	3257.0
Non-Polymers*	Number of molecules	16
	Total formula weight	2405.4
All*	Total formula weight	200247.3

*Water molecules are not included.