8T2J
Structure of the catalytic domain of PPM1D/Wip1 serine/threonine phosphatase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein phosphatase 1D | polymer | 345 | 38261.5 | 1 | UniProt (O15297) Pfam (PF00481) In PDB | Homo sapiens (human) | Protein phosphatase 2C isoform delta,PP2C-delta,Protein phosphatase magnesium-dependent 1 delta,p53-induced protein phosphatase 1 |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: O15297)
| PDB | External Database | Details |
|---|---|---|
| Arg 8 | Gly 8 | engineered mutation |
| Glu 33 | Pro 33 | engineered mutation |
| - | Glu 37 | deletion |
| - | Lys 38 | deletion |
| - | Pro 39 | deletion |
| - | Ser 40 | deletion |
| - | Pro 41 | deletion |
| - | Arg 42 | deletion |
| - | Arg 43 | deletion |
| - | Ser 44 | deletion |
| - | Leu 45 | deletion |
| - | Ser 46 | deletion |
| - | Gln 47 | deletion |
| - | Pro 48 | deletion |
| - | Leu 49 | deletion |
| - | Pro 50 | deletion |
| - | Pro 51 | deletion |
| - | Arg 52 | deletion |
| - | Pro 53 | deletion |
| - | Ser 54 | deletion |
| - | Pro 55 | deletion |
| - | Ala 56 | deletion |
| - | Ala 57 | deletion |
| - | Leu 58 | deletion |
| - | Pro 59 | deletion |
| - | Gly 60 | deletion |
| - | Gly 61 | deletion |
| - | Glu 62 | deletion |
| - | Val 63 | deletion |
| - | Ser 64 | deletion |
| - | Gly 65 | deletion |
| - | Lys 66 | deletion |
| - | Gly 67 | deletion |
| - | Pro 68 | deletion |
| - | Ala 69 | deletion |
| - | Val 70 | deletion |
| - | Ala 71 | deletion |
| - | Ala 72 | deletion |
| - | Arg 73 | deletion |
| - | Glu 74 | deletion |
| - | Ala 75 | deletion |
| - | Arg 76 | deletion |
| - | Asp 77 | deletion |
| - | Pro 78 | deletion |
| - | Leu 79 | deletion |
| - | Pro 80 | deletion |
| - | Asp 81 | deletion |
| - | Ala 82 | deletion |
| - | Gly 83 | deletion |
| - | Ala 84 | deletion |
| - | Ser 85 | deletion |
| - | Pro 86 | deletion |
| - | Ala 87 | deletion |
| - | Pro 88 | deletion |
| - | Ser 89 | deletion |
| - | Arg 90 | deletion |
| - | Cys 91 | deletion |
| - | Cys 92 | deletion |
| - | Arg 93 | deletion |
| - | Arg 94 | deletion |
| Ala 250 | Arg 250 | engineered mutation |
| Ala 258 | Arg 258 | engineered mutation |
| Ala 259 | Arg 259 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38261.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 338.9 | |
| All* | Total formula weight | 38600.4 |
