8T23
Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at upRBD conformation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Angiotensin-converting enzyme | polymer | 771 | 89375.5 | 1 | UniProt (A0A7T0Q2W2) Pfam (PF01401) Pfam (PF16959) In PDB | Neovison vison | |
2 | B | Spike glycoprotein | polymer | 208 | 23370.2 | 1 | UniProt (P0DTC2) Pfam (PF09408) In PDB | Homo sapiens (human) | |
3 | G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
4 | H | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 1 - 739 (UniProt: A0A7T0Q2W2)
B: 321 - 528 (UniProt: P0DTC2)
PDB | External Database | Details |
---|---|---|
Gly 740 | - | expression tag |
Ser 741 | - | expression tag |
Gly 742 | - | expression tag |
Ser 743 | - | expression tag |
Gly 744 | - | expression tag |
Ser 745 | - | expression tag |
Gly 746 | - | expression tag |
His 747 | - | expression tag |
His 748 | - | expression tag |
His 749 | - | expression tag |
His 750 | - | expression tag |
His 751 | - | expression tag |
His 752 | - | expression tag |
Gly 753 | - | expression tag |
Ser 754 | - | expression tag |
Gly 755 | - | expression tag |
Ser 756 | - | expression tag |
Gly 757 | - | expression tag |
Leu 758 | - | expression tag |
Asn 759 | - | expression tag |
Asp 760 | - | expression tag |
Ile 761 | - | expression tag |
Phe 762 | - | expression tag |
Glu 763 | - | expression tag |
Ala 764 | - | expression tag |
Gln 765 | - | expression tag |
Lys 766 | - | expression tag |
Ile 767 | - | expression tag |
Glu 768 | - | expression tag |
Trp 769 | - | expression tag |
His 770 | - | expression tag |
Glu 771 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Phe 453 | Tyr 453 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 112745.7 | |
Branched | Number of molecules | 2 |
Total formula weight | 791.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 113979.9 |