8SYG

Cryo-EM structure of tetradecameric hub domain of CaMKII alpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (B, A, C, D, E...)	Venus-tagged CaMKII Alpha Association Domain	polymer	407	45877.5	14	UniProt (P42212) UniProt (P11275) Pfam (PF01353) Pfam (PF08332)	Aequorea victoria (Water jellyfish Mesonema victoria)

Sequence modifications

B, A, C, D, E, F, G, H, I, J, K, L, M, N: 93 - 329 (UniProt: P42212)

PDB	External Database	Details
Met 72	-	initiating methionine
Gly 73	-	expression tag
Ser 74	-	expression tag
Ser 75	-	expression tag
His 76	-	expression tag
His 77	-	expression tag
His 78	-	expression tag
His 79	-	expression tag
His 80	-	expression tag
His 81	-	expression tag
Ser 82	-	expression tag
Ser 83	-	expression tag
Gly 84	-	expression tag
Leu 85	-	expression tag
Val 86	-	expression tag
Pro 87	-	expression tag
Arg 88	-	expression tag
Gly 89	-	expression tag
Ser 90	-	expression tag
His 91	-	expression tag
Val 92	-	expression tag
Leu 137	Phe 46	conflict
Leu 155	Phe 64	conflict
Gly 156	Ser 65	conflict
Leu 159	Val 68	conflict
Ala 163	Ser 72	conflict
Thr 244	Met 153	conflict
Ala 254	Val 163	conflict
Gly 266	Ser 175	conflict
Tyr 294	Thr 203	conflict
Lys 297	Ala 206	conflict
Leu 322	His 231	conflict
Ser 330	-	linker
Gly 331	-	linker
Leu 332	-	linker
Arg 333	-	linker
Ser 334	-	linker
Arg 335	-	linker
Ala 336	-	linker
Gln 337	-	linker
Ala 338	-	linker
Ser 339	-	linker
Asn 340	-	linker
Ser 341	-	linker
Ala 342	-	linker
Val 343	-	linker
Asp 344	-	linker

B, A, C, D, E, F, G, H, I, J, K, L, M, N: 345 - 478 (UniProt: P11275)

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	642285.5
All*	Total formula weight	642285.5

*Water molecules are not included.