8SXI
CH505 Disulfide Stapled SOSIP Bound to b12 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I | Envelope glycoprotein gp160 | polymer | 456 | 51446.8 | 3 | UniProt (M4M3Q1) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | B, F, J | HIV-1 gp41 | polymer | 126 | 14265.1 | 3 | Pfam (PF00517) UniProt (by SIFTS) (A0A6H1VLP0) In PDB | Human immunodeficiency virus 1 | |
| 3 | C, G, K | b12 Heavy Chain | polymer | 127 | 14371.0 | 3 | Human immunodeficiency virus 1 | ||
| 4 | D, H, L | b12 Light Chain | polymer | 108 | 11877.2 | 3 | Human immunodeficiency virus 1 |
Sequence modifications
A, E, I: 35 - 504 (UniProt: M4M3Q1)
| PDB | External Database | Details |
|---|---|---|
| Glu 32 | - | expression tag |
| Asn 33 | - | expression tag |
| Leu 34 | - | expression tag |
| Ile 68 | Val 64 | conflict |
| Cys 127 | Val 123 | conflict |
| Cys 167 | Asp 154 | conflict |
| Asp 197 | Asn 184 | conflict |
| Val 204 | Ala 191 | conflict |
| Leu 208 | Val 195 | conflict |
| Leu 255 | Val 242 | conflict |
| Lys 279 | Asn 266 | conflict |
| Tyr 458 | Gly 437 | conflict |
| Lys 488 | Glu 467 | conflict |
| Ile 489 | Val 468 | conflict |
| Glu 490 | Lys 469 | conflict |
| Arg 498 | Asn 477 | conflict |
| Cys 499 | Ala 478 | conflict |
| Lys 500 | Arg 479 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 275880.3 | |
| All* | Total formula weight | 275880.3 |
