8SWA
Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S-adenosylmethionine synthase isoform type-1 | polymer | 403 | 44837.1 | 1 | UniProt (Q00266) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) | Homo sapiens (human) | AdoMet synthase 1,Methionine adenosyltransferase 1,MAT 1,Methionine adenosyltransferase I/III,MAT-I/III |
| 2 | B (A) | (DIPHOSPHONO)AMINOPHOSPHONIC ACID | non-polymer | 257.0 | 1 | Chemie (PPK) | |||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | F (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 6 | G (A) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A: 16 - 395 (UniProt: Q00266)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Val 3 | - | expression tag |
| Asp 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gly 6 | - | expression tag |
| Thr 7 | - | expression tag |
| Glu 8 | - | expression tag |
| Asn 9 | - | expression tag |
| Leu 10 | - | expression tag |
| Tyr 11 | - | expression tag |
| Phe 12 | - | expression tag |
| Gln 13 | - | expression tag |
| Ser 14 | - | expression tag |
| Met 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44837.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 743.1 | |
| All* | Total formula weight | 45580.2 |
