8SW4

BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	21M20 heavy chain variable region	polymer	125	13737.4	1		Macaca
2	B (L)	21M20 light chain variable region	polymer	107	11358.6	1		Macaca
3	C, G, K (A, C, D)	BG505 GT1.1 SOSIP gp120	polymer	509	57275.5	3	Pfam (PF00516) UniProt (by SIFTS) (Q2N0S6)	Human immunodeficiency virus 1
4	D, H, L (B, G, I)	Envelope glycoprotein gp41	polymer	153	17146.5	3	UniProt (Q2N0S6) Pfam (PF00517)	Human immunodeficiency virus 1	Env polyprotein
5	E, I, M (E, J, K)	RM20A3 heavy chain variable region	polymer	124	13424.0	3		Macaca
6	F, J, N (F, M, N)	RM20A3 light chain variable region	polymer	111	11755.8	3		Macaca
7	O, Q, S (O, Q, S)	21N13 heavy chain variable region	polymer	130	14476.9	3		Macaca
8	P, R, T (P, R, T)	21N13 light chain variable region	polymer	107	11757.1	3		Macaca
9	U, W, X (U, W, X)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	3	In PDB GlyTouCan (G81315DD)
10	V (V)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
11	AA, AB, BA, BB, CA... (A, D, I, B, C...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	33	Chemie (NAG)

Sequence modifications

B, G, I: 512 - 664 (UniProt: Q2N0S6)

PDB	External Database	Details
Pro 559	Ile 556	engineered mutation
Cys 605	Thr 602	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	402603.3
Branched	Number of molecules	4
	Total formula weight	2670.4
Non-Polymers*	Number of molecules	33
	Total formula weight	7299.9
All*	Total formula weight	412573.7

*Water molecules are not included.