8SVQ
Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-312
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide | polymer | 351 | 39895.6 | 2 | UniProt (O75469) UniProt (Q15788) Pfam (PF00104) Pfam (PF08832) In PDB | Homo sapiens (human) | |
2 | A, B | (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide | non-polymer | 494.6 | 2 | Chemie (WSX) | |||
3 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
4 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 434 (UniProt: O75469)
A, B: 441 - 473 (UniProt: Q15788)
PDB | External Database | Details |
---|---|---|
His 123 | - | expression tag |
His 124 | - | expression tag |
His 125 | - | expression tag |
His 126 | - | expression tag |
His 127 | - | expression tag |
His 128 | - | expression tag |
Gly 129 | - | expression tag |
Ser 435 | - | linker |
Gly 436 | - | linker |
Gly 437 | - | linker |
Ser 438 | - | linker |
Gly 439 | - | linker |
Gly 440 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79791.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1067.4 | |
All* | Total formula weight | 80858.7 |