8SSA

Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera	polymer	1026	114978.9	4	UniProt (P19491) UniProt (Q8VHW8) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF13903)	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-5 subunit,Transmembrane AMPAR regulatory protein gamma-5,TARP gamma-5
2	E, F (E, F)	Protein cornichon homolog 2	polymer	160	18948.4	2	UniProt (Q6PI25) Pfam (PF03311)	Homo sapiens (human)	CNIH-2,Cornichon family AMPA receptor auxiliary protein 2,Cornichon-like protein
3	G, H, I, K, L... (A, B, C, D)	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	12	Chemie (PCW)
4	J, N, R, V (A, B, C, D)	GLUTAMIC ACID	non-polymer		147.1	4	Chemie (GLU)
5	W (D)	SPERMIDINE	non-polymer		145.2	1	Chemie (SPD)

Sequence modifications

A, B, C, D: 10 - 826 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	conflict
Leu 382	Val 397	conflict
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	conflict
Asp 385	Asn 406	conflict
Gln 392	Asn 413	conflict
Ser 754	Asn 775	conflict
Val 758	Leu 779	conflict
Gly 827	-	linker
Thr 828	-	linker
Gly 829	-	linker
Ser 830	-	linker
Ala 831	-	linker

A, B, C, D: 832 - 1035 (UniProt: Q8VHW8)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	497812.3
Non-Polymers*	Number of molecules	17
	Total formula weight	10179.2
All*	Total formula weight	507991.5

*Water molecules are not included.