8SO0
Cryo-EM structure of the PP2A:B55-FAM122A complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 584 | 64958.0 | 1 | UniProt (P30153) Pfam (PF02985) In PDB | Homo sapiens (human) | Medium tumor antigen-associated 61 kDa protein,PP2A subunit A isoform PR65-alpha,PP2A subunit A isoform R1-alpha |
| 2 | B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | polymer | 451 | 52101.3 | 1 | UniProt (P63151) In PDB | Homo sapiens (human) | PP2A subunit B isoform B55-alpha,PP2A subunit B isoform PR55-alpha,PP2A subunit B isoform R2-alpha,PP2A subunit B isoform alpha |
| 3 | C | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 311 | 35845.4 | 1 | UniProt (P67775) Pfam (PF00149) In PDB | Homo sapiens (human) | PP2A-alpha,Replication protein C,RP-C |
| 4 | D | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 | polymer | 95 | 10680.9 | 1 | UniProt (Q96E09) In PDB | Homo sapiens (human) | PABIR family member 1 |
| 5 | C | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 6 | C | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 9 - 589 (UniProt: P30153)
B: 2 - 447 (UniProt: P63151)
C: 1 - 309 (UniProt: P67775)
D: 29 - 120 (UniProt: Q96E09)
| PDB | External Database | Details |
|---|---|---|
| Gly 6 | - | expression tag |
| His 7 | - | expression tag |
| Met 8 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| His -2 | - | expression tag |
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 26 | - | expression tag |
| His 27 | - | expression tag |
| Met 28 | - | expression tag |
| Ser 47 | Thr 47 | conflict |
| Asp 53 | Ala 53 | conflict |
| Arg 62 | Ser 62 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 163585.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 121.3 | |
| All* | Total formula weight | 163706.9 |
