8SNM
Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Inactive rhomboid protein 2 | polymer | 827 | 93503.3 | 1 | UniProt (Q6PJF5) Pfam (PF12595) Pfam (PF01694) | Homo sapiens (human) | iRhom2,Rhomboid 5 homolog 2,Rhomboid family member 2,Rhomboid veinlet-like protein 5,Rhomboid veinlet-like protein 6 |
| 2 | B (A) | Disintegrin and metalloproteinase domain-containing protein 17 propeptide | polymer | 214 | 24857.3 | 1 | UniProt (P78536) | Homo sapiens (human) | ADAM 17,Snake venom-like protease,TNF-alpha convertase,TNF-alpha-converting enzyme |
| 3 | C (B) | Disintegrin and metalloproteinase domain-containing protein 17 | polymer | 610 | 68302.6 | 1 | UniProt (P78536) Pfam (PF13688) Pfam (PF00200) Pfam (PF16698) | Homo sapiens (human) | ADAM 17,Snake venom-like protease,TNF-alpha convertase,TNF-alpha-converting enzyme |
| 4 | D (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 186663.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 105.5 | |
| All* | Total formula weight | 186768.7 |
