8SNL
Structure of human ADAM17/iRhom2 sheddase complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Disintegrin and metalloproteinase domain-containing protein 17 | polymer | 824 | 93141.9 | 1 | UniProt (P78536) Pfam (PF13688) Pfam (PF00200) Pfam (PF16698) In PDB | Homo sapiens (human) | ADAM 17,Snake venom-like protease,TNF-alpha convertase,TNF-alpha-converting enzyme |
| 2 | B | Inactive rhomboid protein 2 | polymer | 827 | 93503.3 | 1 | UniProt (Q6PJF5) Pfam (PF12595) Pfam (PF01694) In PDB | Homo sapiens (human) | iRhom2,Rhomboid 5 homolog 2,Rhomboid family member 2,Rhomboid veinlet-like protein 5,Rhomboid veinlet-like protein 6 |
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 186645.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 105.5 | |
| All* | Total formula weight | 186750.7 |
